Comparison of the surface properties of raw, micronized and conditioned lactoses

The surface properties of lactose play an essential role for the behavior of these powder in inhalers. The different Inverse Gas chromatography methods are providing very interesting tools for characterizing the surface of lactose powders.
This application note compares the surface characteristics of a same lactose powder different stages of the preparation process in order to be used in inhalers (not milled, milled and conditioned). The determined surface characteristics are: the surface energy, nanoroughness, acid-base character, specific surface area and adsorption energy distribution functions.

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